It was a lot of fun.
Drinks and snacks available too. Im now hooked on live comedy. More people need to try this. It is a great night out. World class comedy venue to perform at, to watch, or just to have a drink and laugh with friends. Vaughan and the staff are brilliant, try the elephant dump shot it will blow your mind. Fantastic venue for a night out in Wellington. Great bar and the acts are always awesome. A great place to get a slice of New Zealand's comedy scene while you're in Welly. Went there with a group of friends and watched 8 live comedy performers - was a great show and extremely funny.
Wasn't overly convinced before going but was well worth the entry fee, and would definitely go again if I am back in Wellington. Flights Vacation Rentals Restaurants Things to do. All of your saved places can be found here in My Trips.
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Log in to get trip updates and message other travelers. Log in Join Recently viewed Bookings Inbox. VK's Comedy and Blues Bar. Reviewed January 11, Reviewed October 29, Powered by Weather Underground. TripAdvisor has been notified. This property is closed Report incorrect address Suggest edits.
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Beepen-VK - Clinical Pharmacology
Half-Day Wellington Foodie Experience. See what travelers are saying:. However, resistance to penicillin G by beta-lactamase—producing N. Some other organisms for which penicillin G has good activity include Actinomyces israelii , Bacillus anthracis , oropharyngeal Bacteroides species, Borrelia burgdorferi , Clostridium sp. These penicillins are active against both penicillin-sensitive and penicillin-resistant staphylococci, as well as Streptococcus pyogenes and Streptococcus pneumoniae. The antipseudomonal penicillins are active against a wide variety of gram-negative bacteria, including P.
Ticarcillin is 2 to 4 times more active than carbenicillin against P. Pivmecillinam is hydrolyzed during absorption to liberate the active agent, mecillinam. Mecillinam has poor activity against gram-positive organisms, Haemophilus , and Neisseria species; however, it has very good activity against many gram-negative bacteria, including E.
It has variable activity against Proteus sp. Arthritis, gonococcal treatment —Penicillin G parenteral is indicated in the treatment of infective arthritis caused by susceptible strains of N. Erysipeloid treatment —Penicillin G parenteral , [penicillin V] 1 , [penicillin G benzathine] 1 , and [penicillin G procaine] 1 are indicated in the treatment of erysipeloid, including endocarditis and septicemia, caused by E.
However, because of resistance to penicillin, other agents, such as ceftriaxone, cefixime, or ciprofloxacin, are considered to be first-line agents. Syphilis treatment —Penicillin G benzathine is indicated in the treatment of primary, secondary, and early and late latent syphilis.
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Bactericidal; inhibit bacterial cell wall synthesis. Action is dependent on the ability of penicillins to reach and bind penicillin-binding proteins PBPs located on the inner membrane of the bacterial cell wall. PBPs which include transpeptidases, carboxypeptidases, and endopeptidases are enzymes that are involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division.
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Penicillins are widely distributed to most tissues and body fluids, including peritoneal fluid, blister fluid, urine high concentrations , pleural fluid, middle ear fluid, intestinal mucosa, bone, gallbladder, lung, female reproductive tissues, and bile. Distribution into the cerebrospinal fluid CSF is low in subjects with noninflamed meninges, as is penetration into purulent bronchial secretions. Primarily renal glomerular filtration and tubular secretion. Studies in mice and rats at doses up to 10 times the human dose of amoxicillin revealed no evidence of impaired fertility.
Also, bacampicillin had no effect on the reproductive organs of rats or dogs receiving daily oral doses of up to and mg, respectively, for 6 months.
Reproductive studies performed in the mouse, rat, and rabbit given these penicillins have revealed no evidence of impaired fertility. Studies in mice and rats given doses up to twice the usual human dose have not shown that mezlocillin impairs fertility. Studies in mice and rats given doses up to 4 times the human dose of piperacillin have shown no evidence of impaired fertility.
Reproductive studies done in mice and rats given ticarcillin have revealed no evidence of impaired fertility. Adequate and well-controlled studies in humans have not been done to determine whether penicillins are teratogenic; however, penicillins are widely used in pregnant women and problems have not been documented. Studies in mice and rats at doses up to 10 times the human dose of amoxicillin revealed no evidence of harm to the fetus.
Studies in animals given doses several times the human dose have revealed no evidence of adverse effects in the fetus. Cloxacillin, dicloxacillin, methicillin, nafcillin, oxacillin, penicillin G, penicillin V: Reproductive studies performed in the mouse, rat, and rabbit given these penicillins have revealed no evidence of impaired fertility or harm to the fetus. Safety during pregnancy has not been established. Studies in mice and rats given doses up to twice the usual human dose have not shown that mezlocillin causes adverse effects in the fetus.
Studies in mice and rats given doses up to 4 times the usual human dose have not shown that piperacillin causes adverse effects in the fetus. Reproductive studies done in mice and rats given ticarcillin have not shown that ticarcillin causes adverse effects in the fetus. Breast-feeding Penicillins are distributed into breast milk, some in low concentrations. However, the incompletely developed renal function of neonates and young infants may delay the excretion of renally eliminated penicillins.
These dosage forms should be used with caution, if at all, in patients with phenylketonuria. The other strengths and dosage forms of amoxicillin do not contain phenylalanine. However, elderly patients are more likely to have age-related renal function impairment, which may require an adjustment in dosage in patients receiving penicillins.