Dating pregnancy blood test

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For Democratic senators eyeing bids, committee hearings become campaign platform. In the study, published Thursday in the journal Science, the team, which was co-led by Dr. Mads Melbye, who runs the Statens Serum Institute in Denmark, analyzed the blood of 31 Danish women taken every week throughout their pregnancies, which were all full-term.

The researchers studied genes linked to the placenta, the maternal immune system and the fetal liver, and found nine of those genes produce RNA signals that change distinctly as pregnancy progresses. The researchers then applied the test to two groups of women at risk for preterm birth — patients at the University of Pennsylvania who had premature contractions and patients at the University of Alabama, Birmingham, who had delivered prematurely in a previous pregnancy.

Blood Test Predicts Pregnancy Due Date

But in analyzing the blood of some of the women who delivered prematurely, the team identified seven other genes with RNA signals that seemed to characterize preterm birth. Quake said the team is developing plans for a large clinical trial in the general population.

Diana Bianchi, director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development and an expert in prenatal genetic testing, said a trial should involve as much diversity as possible. The method, described today June 7 in Science , also enabled the researchers to predict, in most cases, which of the high-risk pregnancies would end prematurely. He adds that such a blood test would be especially useful in developing countries where ultrasound is not readily available.

The researchers zeroed in on nine transcripts known to originate in the placenta whose levels corresponded with pregnancy progression.